Pleiotropy occurs when a single gene affects multiple traits – hence mutations will issues arising from sickle cell anaemia (mutation to the beta-globin gene).


If an animal has a gene that affects both the length and color of its fur, the gene is considered pleiotropic. Pleiotropy is a condition in which a single gene influences more than one phenotypic trait in an organism.

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Pleiotropic gene

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The gene pleiotropy is also referred to as 'Molecular Gene Pleiotropy. The gene which focuses on the Human Gene Disorders. The genes affected by human genetic disorders are mostly pleiotropic genes. Examples of Pleiotropy. Phenylketonuria is In genetics, pleiotropy is the property in which a gene can affect more than one function or phenotype in an organism. Studies have shown that genes can have varying degrees of pleiotropy and that, on average, deleting genes with higher degrees of pleiotropy has harmful effects on the organism (Guillaume & Otto, 2012). Pleiotropic genes and health.

Pleiotropic genes and health. Where a genetic condition affects multiple tissues or organs, this can often be the result of pleiotropy. An example would be Marfan syndrome, which is caused by variation in the FBN1 gene. People with Marfan syndrome tend to be tall with long thin fingers, toes and limbs.

At molecular level, we can say that the product formed by this gene plays role in different pathways associated with expression of different traits. Pleiotropy is defined as one gene influencing more than one trait. Pleiotropy, together with linkage disequilibrium due to physical linkage or population structure, causes genetic correlations among traits.

Pleiotropic gene

Pleiotropy is a condition in which a single gene influences more than one phenotypic trait in an organism. A phenotypic trait is any observable trait, in contrast to a genotypic trait, which is involved with the genetic composition of an organism.

Pleiotropic gene

Finally, pleiotropy could be least constraining when genetic pathways diverge soon after the pleiotropic gene (e.g.

also plei·ot·ro·pism n. Biology The production of diverse effects, especially the production by a single gene of several distinct and seemingly unrelated Pleiotropic definition, responsible for or affecting more than one phenotypic characteristic: Scientists are trying to determine if the various effects of pleiotropic genes are sensitive in different ways to different environmental influences. 2010-11-30 · New approach for rice improvement using a pleiotropic QTL gene for lodging resistance and yield. Nat. Commun. 1:132 doi: 10.1038/ncomms1132 (2010).
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Forskningsoutput: Tidskriftsbidrag › Debate/Note/Editorial. Översikt · Cite · Bibtex  Squamous cell carcinomas (SqCC) of the aerodigestive tract have similar etiological risk factors. Although genetic risk variants for individual  The p13 gene, situated on the chromosome, encodes a channel-forming protein that belongs to the gene family 48 consisting of eight additional paralogous  av AC Karlsson · 2014 — One single gene can control several different traits (pleiotropy), that a mutation in the PMEL17 and TSHR genes have pleiotropic effects on  The human long non-coding RNA gene RMRP has pleiotropic effects and regulates cell-cycle progression at G2. Svetlana Vakkilainen, Tiina Skoog, Elisabet  other genes in the system. Contrarily, selection on the highly pleiotropic POMC gene, which orchestrates the activation of the different melanocortin receptors,  Additional adverse effects, for example, pleiotropic effects, might have been For gene and somatic cell therapy medicinal products, it is recognised that  Genetic pleiotropy, the ability of a mutation in a single gene to give rise to multiple phenotypic outcomes, constitutes an important but incompletely understood  Artikel Seed traits are pleiotropically regulated by the flowering time gene PERPETUAL FLOWERING 1 (PEP1) in the perennial Arabis alpina. 2019.

What is Pleiotropy in Genetics? In genetics, Pleiotropy is defined as the expression of multiple traits by a single gene. Pleiotropy is derived from a Greek word  Pleiotropic gene definition at, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
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Pleiotropic Gene Known as: Gene, Pleiotropic , Genes, Pleiotropic , Pleiotropic Genes A single gene that influences several distinct and seemly unrelated phenotypic outcomes.

By definition, pleiotropy is a situation in which one gene controls for the expression of multiple phenotypic traits. These traits don’t have to be clearly linked, i.e., eye shape and eye color, but can instead be completely unrelated.

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Artikel Seed traits are pleiotropically regulated by the flowering time gene PERPETUAL FLOWERING 1 (PEP1) in the perennial Arabis alpina. 2019. Patrick 

Pleiotropic Effects of SOX10. Pleiotropy can arise through several mechanisms. Gene pleiotropy occurs when a gene has various functions due to encoding a product that interacts with … Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:28076346). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing (PubMed:11101529, PubMed:11544257). 2020-03-12 2020-05-30 Pleiotropic genes act as an arbitrating force in speciation.; Likewise, pleiotropic gene's stabilizing selection allows for the allele frequency to be altered. Another evolutionary theory of aging was proposed by pleiotropic genes that are beneficial early in life but harmful later on.; Andrzej P kalski, from the University of WrocB aw, argues that eugenics can cause harmful loss of genetic Pleiotropy (from Greek πλείων pleion, "more", and τρόπος tropos, "way") occurs when one gene influences two or more seemingly unrelated phenotypic traits.